M. Weidenhiller

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OBJECTIVE:Mast cells are thought to participate in the pathogenesis of inflammatory bowel disease (IBD). In this study, urinary excretion of N-methylhistamine (UMH), a stable metabolite of the mast cell mediator histamine, was evaluated as an indicator of disease activity in patients with IBD.METHODS:Urinary excretion of UMH (μg/mmol creatinine × m2 body(More)
Pathobiology of dysplasia in chronic inflammatory bowel disease: Current recommendations for surveillance of dysplasia. Patients with ulcerative colitis and Crohn's disease bear an about 10- and 4-fold increased risk, respectively, for developing colorectal carcinoma. Apart from typical locations of colorectal carcinoma in the sigmoid colon and rectum other(More)
Corticosteroids and 5-aminosalicylic acid are the primary standard therapy for inflammatory bowel disease. Recent immunologic data implicate an involvement of mast cell activation followed by increased histamine secretion and elevated tissue concentrations of histamine in the pathogenesis of ulcerative colitis. In the present case, the clinical course of a(More)
Allergy frequency is still increasing in industrial countries, but monitoring of allergic and inflammatory conditions may be difficult. The incidence of allergy and elevated IgE serum levels has been reported to decrease with age. The measurement of urinary excretion of N-tele-methylhistamine is a valuable diagnostic tool to monitor disease activity in(More)
AIM This study evaluated colorectal mucosal histamine release in response to blinded food challenge-positive and -negative food antigens as a new diagnostic procedure. METHODS 19 patients suffering from gastrointestinally mediated allergy confirmed by blinded oral provocation were investigated on grounds of their case history, skin prick tests, serum IgE(More)
Gastrointestinal complaints after ingestion of certain foodstuffs often pose diagnostic problems in various clinical situations like food hypersensitivity, irritable bowel syndrome, inflammatory bowel disease etc [1]. A functional histamine release from intact human biopsies of the small intestine has been described in 1989 [2]. This study investigated(More)
Food allergy (FA) involves approximately 2–5% of general population with increasing rates of incidence [1]. Apart from allergen avoidance, many patients with FA try either additional established therapeutics (mast cell stabilisers, antihistamines) or unconventional treatment forms like acupuncture, probiotics, pancreatic enzymes or psychosomatics [1, 2].(More)