M. W. Dünser

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UNLABELLED We retrospectively investigated the effects of continuous arginine vasopressin (AVP) infusion on systemic hemodynamics, acid/base status, and laboratory variables in patients (mean age [mean +/- SD]= 66.3 +/- 10.1 yr) with catecholamine-resistant septic (n = 35) or postcardiotomy shock (n = 25). Hemodynamic and acid/base data were obtained(More)
BACKGROUND Low-molecular-weight heparins (LMWHs) have become increasingly used to prevent thromboembolic complications in intensive care patients. Unlike in medical and surgical patients, no data on the anticoagulant effectiveness of standard LMWH dosages exist in intensive care patients. Therefore, we prospectively investigated antifactor Xa (aFXa) levels(More)
Ziele der Beatmung eines ungeschützten Atemweges sind Oxygenierung und Kohlendioxidelimination des Patienten. Dies kann mit Techniken, wie der Mund-zu-Mund- oder besser der Maskenbeatmung, erreicht werden. Zur Atemwegssicherung ist die Intubation der Goldstandard; allerdings hängt hier der Erfolg, v. a. im Notfall, von der initialen Ausbildung und einem(More)
The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle contraction to oxygen consumption of the microvascular wall during arginine vasopressin (AVP)-induced vasoconstriction. AVP was infused intravenously at the clinical dosage(More)
Objective. Arginine-vasopressin (AVP) might be a potent vasopressor agent in catecholamine-resistant postcardiotomy shock. However, its use remains experimental because of considerations about deleterious effects on the heart. We report on the effects of continuous AVP-infusion on cardiac performance, biomarkers of myocardial ischemia, and systemic(More)
The goal of ventilation in an unprotected airway is to optimize oxygenation and carbon dioxide elimination of the patient. This can be achieved with techniques such as mouth-to-mouth ventilation, but preferably with bag-valve-mask ventilation. Securing the airway with an endotracheal tube is the gold standard, but excellent success in emergency airway(More)
Im therapierefraktären traumatisch-hämorrhagischen Schock ist eine Stabilisierung des Blutdrucks mit aggressiver Volumengabe und Katecholaminen teilweise nicht mehr möglich. In diesen Zuständen konnten mit Vasopressin in experimentellen Untersuchungen und in Fallserien eine Steigerung des arteriellen Blutdrucks, eine Umverteilung des noch zirkulierenden(More)
BACKGROUND Tachyarrhythmias (TA) represent a frequent and serious problem after cardiac surgery. We retrospectively analyzed 987 cardiac surgery patients admitted to a surgical intensive care unit between 1996 and 1999 to assess incidence and risk factors associated with development of postoperative TA in the intensive care unit. METHODS TA (n=149) were(More)
While fluid management is established in controlled hemorrhagic shock, its use in uncontrolled hemorrhagic shock is being controversially discussed, because it may worsen bleeding. In the irreversible phase of hemorrhagic shock that was unresponsive to volume replacement, airway management and catecholamines, vasopressin was beneficial due to an increase in(More)
BACKGROUND Plasma copeptin levels before and during exogenous arginine vasopressin infusion (AVP) were evaluated, and the value of copeptin levels before AVP therapy to predict complications during AVP therapy and outcome in vasodilatory shock patients was determined. METHODS This prospective, observational study was nested in a randomized, controlled(More)