M. W. Chen

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Improving models of human stroke by the use of aged animals has been advocated; however the commonly used rat middle cerebral artery thread-occlusion model has produced suboptimal stroke induction and excess mortality in aged rats. We report the development of a modified method for silicone-coating the tip of occluding threads which produces a malleable(More)
BACKGROUND & AIMS Alterations in central corticotropin-releasing factor signaling pathways have been implicated in the pathophysiology of anxiety disorders and irritable bowel syndrome (IBS). We aimed to characterize the effects of the corticotropin-releasing factor receptor 1 (CRF-R1) antagonist, GW876008, on brain and skin conductance responses during(More)
BACKGROUND AND PURPOSE The ischemic penumbra is a major focus of stroke research. 18F-fluoromisonidazole (18F-FMISO), a positron emission tomography (PET) marker of hypoxic cells, has shown promise as a technique to image the penumbra in humans. Our aim was to delineate the pattern of 18F-FMISO binding in a rat middle cerebral artery transient(More)
BACKGROUND AND PURPOSE Traditional neuroimaging techniques restrict movement and make it difficult to study the processes that require oral, upper limb, or lower limb motor execution. Functional near-infrared spectroscopy (fNIRS) is an optical neuroimaging modality that measures brain oxygenation and permits movement during data acquisition. A key(More)
With the large corpora of clinical texts, natural language processing (NLP) is growing to be a field that people are exploring to extract useful patient information. NLP applications in clinical medicine are especially important in domains where the clinical observations are crucial to define and diagnose the disease. There are a variety of different(More)
CONTEXT Unexplained fatigue states are prevalent, with uncertain diagnostic boundaries. OBJECTIVE Patients with fatigue-related illnesses were investigated by questionnaire and a novel semistructured interview to identify discriminatory features. METHODS Cross-sectional samples of women from specialist practices with chronic fatigue syndrome (n = 20),(More)
Background and Purpose—The ischemic penumbra is a major focus of stroke research. 18 F-fluoromisonidazole (18 F-FMISO), a positron emission tomography (PET) marker of hypoxic cells, has shown promise as a technique to image the penumbra in humans. Our aim was to delineate the pattern of 18 F-FMISO binding in a rat middle cerebral artery transient(More)
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