OBJECTIVE To test for genetic linkage and association with GABAergic candidate genes in lithium-responsive bipolar disorder. DESIGN Polymorphisms located in genes that code for GABRA3, GABRA5 and GABRB3 subunits of the GABAA receptor were investigated using association and linkage strategies. PARTICIPANTS A total of 138 patients with bipolar 1 disorder… (More)
The 21 HLA-A and -B antigens were typed in 38 patients with the senile form of Alzheimer's disease and 301 healthy individuals. No statistically significant difference was found in the frequency of HLA antigens after correction of P.
In a review of the literature the author outlines the basic ethical problems of contemporary European gerontopsychiatry, as apparent at international congresses of gerontopsychiatric societies in Berlin (1993 and 1994) and Amsterdam (1994). Ethical dilemmas include in the first place abuse of old people, ethics of drug trials with insane patients and the… (More)
The paper offers a brief outline of the current state of geriatric psychiatry and psychopharmacology in Canada and partially in the USA. Major trends are described in clinical care, in organization and education, along with some basic historical comments. The important role of self-help groups is sketched. The contents of recent major scientific meetings… (More)