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The objective of this study was to investigate the reliability of a fragmental approach to build a full-length model of the human ghrelin receptor (hGHS-R1a) in its open state. The soundness of the model was verified by docking the tetrapeptide Gly-Ser-Ser(n-octanoyl)-Phe-NH2, which represents the ghrelin active core, and a dataset of 35 peptidomimetic GH(More)
We performed this study with the aims of describing the trend of asthma-related mortality in Italy between 1980 and 1994, and to evaluate the relationship between sale estimates of β2-agonists drugs and mortality from asthma. For asthma mortality we used data provided by National Institute of Statistics, for sale estimates of β2-agonists we used data(More)
A novel model for the coupling between ventricular repolarisation and heart rate (QT/RR) is presented. It is based upon a transfer function (TRF) formalism that describes the static and dynamic properties of this coupling, i.e., the behaviour after a sudden change in heart rate. Different TRF models were analysed by comparing their capability to describe(More)
Cardiac repolarization is assessed by the QT interval on the surface electrocardiogram and varies with the heart rate. Standard QT corrections (QTc) do not account for the lag in QT change following a change in heart rate (QT hysteresis). Our group has developed and tested a transfer function (TRF) model to assess the effectiveness of a dynamic model of(More)
28 Patienten, Träger von bösartigen Neoplasien des Rectum-Sigmabezirkes, von denen fünf eine Invadierung des Afterkanals aufweisen, sind mit der Lymphographie, manchmal mit der Cavographie vereint, studiert worden. Der häufig positive Nachweis von Metastasen in den epi- und paracolischen Lymphknoten im Gegensatz zu der lymphographischen sowie histologischen(More)