M. V. Zykova

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The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic(More)
Diagnostic properties of humic acids of lowland wood-grass peat from Klyukvennoe deposit (Tomsk Region) were studied. Criteria for the identification and quality estimation of humic acids obtained from this source were established. The results showed the expediency of using these criteria as the standardization parameters.
A screening study of biological activity of native humic acids isolated from peat was performed; several physical and chemical parameters of their structures were studied by UV- and infrared spectroscopy. Spectroscopy yielded similar shape of light absorption curves of humic acids of different origin, which can reflect similarity of general structural(More)
The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia(More)
Peat humic acids (PHAs) were found under experimental normobaric hypoxia with hypercapnia to normalize the activities of succinate- and NAD-dependent energy-production processes and to prevent disconnection of oxidative phosphorylation in mouse cerebral and hepatic mitochondria. The antihypoxic activity of PHAs was comparable with that of the reference(More)
The active ingredient extracted from the peat humic substances was characterized by physicochemical parameters evaluated by UV- and IR-spectroscopy, titration, and elemental (C, H, N) analysis. The cardiovascular effects of this ingredient were examined on isolated Langendorff-perfused rat heart. It was found that the active substance in a concentration(More)
We studied activation of macrophages with humic acids extracted from peat of large deposits in the Tomsk region by two extraction methods: by hydroxide or sodium pyrophosphate. Humic acid of lowland peat types containing large amounts of aromatic carbon, phenolic and alcohol groups, carbohydrate residues and ethers, irrespectively of the extraction methods(More)
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