M. V. Chernikov

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A three-arm study comparing the efficacy of Kan Jang, a fixed herbal combination containing standardized Andrographis paniculata (N.) SHA-10 extract, with Immunal, a preparation containing Echinacea purpurea (L.) extract, in uncomplicated common colds was carried out in 130 children aged between 4 and 11 years over a period of 10 days. The study was(More)
A series of 9-dialkylaminoethyl-2-oxy(dioxy)phenylimidazo[1,2-a]benzimidazoles have been synthesized and their pharmacological properties have been studied. Some compounds exhibit pronounced antioxidant activity, as confirmed on experimental pathological models in animals. The tests also revealed membranotropic, spasmolytic, antiaggregant, hemorheological,(More)
This study was designed as a comparative experimental analysis of the gastroprotective effects of two H2-blocking agents--famotidine and benzimidazole compound 64--on the model rat stomach Helicobacter-like mucous lesions. Both substances demonstrated dose-dependent gastroprotective effects both on the macro- and microscopic levels. ED50 made up 21.8 mg/kg(More)
Discovery of the third subtype of histamine receptors dates back to 1979, when Schwartz suggested that the effect of some agents upon the CNS can be mediated by receptors other than those of the H1 and H2 types. Indeed, the new receptors were originally described in 1983 by Arrang et al. and called H3 receptors. Histamine receptors of the H3 type belong to(More)
Impairment of endothelial function forms basis for many cardiovascular diseases, therefore today it becomes an independent target for therapeutic action, and the search for new compounds possessing endothelium-protective properties is one of the prospective goals of the pharmacotherapy and medicinal chemistry. An efficient instrument to solve the problem is(More)
A series of 2-methoxy-and 2-oxyphenyl-1-dialkylaminoalkylimidazo[1,2-a]benzimidazoles have been synthesized and characterized with respect to pharmacological properties. Some of the synthesized compounds exhibit antioxidant, membranotropic, antiaggregant, hemorheological, anticalmodulin, and hypotensive properties, and behave as antagonists of serotonin(More)
Participating in the genesis of many pathologic states, histamine is one of the most essential biological amines. The corresponding effects are mediated by histamine receptors of three types: Hi, H 2, and H 3 [1, 2]. Excitation of the H l receptors leads to characteristic pathophysiological changes manifested in a number of disorders (mostly allergic) [2].(More)
Efficacy and safety of bisoprolol in hypertensive patients with cardiovascular disease and chronic obstructive pulmonary disease. A comparative study on the efficacy and safety of bisoprolol and sustained release metoprolol succinate in patients with arterial hypertension (AH), cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD)(More)
A randomized trial of the effectiveness of the preparation Kan-Yang (Sweden) consisting of andrographis and eleutherococcus extracts was performed in 53 children with acute respiratory viral infection (ARVI). 40 ARVI children given conventional treatment served control. It is shown that in early acute noncomplicated respiratory disease Kan-Yang tablets(More)
Taking into account the structure—activity relationship established previously for imidazobenzimidazole derivatives with high hemorheological activity, several new 9-R-2-halogenophenyl-substituted imidazo[1,2-a]benzimidazoles with C2 fluoro-, chloro-, dichloro-, or bromo-phenyl radicals have been synthesized. All substances were tested in vitro for various(More)