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Almost all of the data on the biological effects of ionizing radiation come from studies of high doses. However, the human population is unlikely to be exposed to such doses. Regulatory limits for radiation exposure are based on the linear no-threshold model, which predicts that the relationship between biological effects and radiation dose is linear, and(More)
Somatic intrachromosomal recombination can result in inversions and deletions in DNA, which are important mutations in cancer. The pKZ1 chromosomal inversion assay is a sensitive assay for studying the effects of DNA damaging agents using chromosomal inversion as a mutation end-point. We have previously demonstrated that the chromosomal inversion response(More)
This correspondence comments on cryptography as a (written in the English alphabet) can be uniquely coded with the<lb>vocation or avocation for the systems scientist. A nontrivial challenge G-code, and of course, given the "key" to the G-code, one should<lb>is included.<lb>have no difficulty in deciphering the above cryptogram or any other message written(More)
An adaptive response is a response to a stress such as radiation exposure that results in a lower than expected biological response. We describe an adaptive response to X radiation in mouse prostate using the pKZ1 chromosomal inversion assay. pKZ1 mice were treated with a priming dose of 0.001, 0.01, 1 or 10 mGy followed 4 h later by a 1000-mGy challenge(More)
Adaptive responses are induced by stress such as X radiation and result in a lower than expected biological response. Two-dose adaptive response experiments typically involve a low priming dose followed by a subsequent high radiation dose. Here, we used a sensitive in vivo chromosomal inversion assay to demonstrate for the first time an adaptive response(More)
Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (microGy to cGy range) in a whole animal model. The mutational end-point studied(More)
The pKZ1 mouse chromosomal inversion assay is the only assay that has detected modulation of a mutagenic endpoint after single whole body X-irradiation with doses lower than 1 mGy. A non-linear dose response for chromosomal inversion has been observed in spleen and prostate between 0.001 mGy and 10 mGy, with doses between 0.005-0.01 mGy causing an increase(More)
  • M. V. Bhat
  • Australasian Physical & Engineering Sciences in…
  • 2010
The world’s two worst industrial disasters occurred in the early years of my career in radiation physics. The Bhopal gas tragedy was the worst industrial accident and occurred on the night of December 2–3, 1984 at the Union Carbide pesticide plant in Bhopal, India and killed 10,000 people on that one night. The worst ever nuclear accident occurred at the(More)
Thomson and Nielsen TN-502 RD MOSFETs were used for entrance dose in vivo dosimetry for 6 and 10 MV photons. A total of 24 patients were tested, 10 breast, 8 prostate, 5 lung and 1 head and neck. For prostates three fields were checked. For all other plans all fields were checked. An action threshold of 8% was set for any one field and 5% for all fields(More)
Commercially available MOSFETs, Thomson and Nielsen TN502-RD, were evaluated for suitability as an entrance dose in vivo dosimeter for 6MV and 10MV. Detector response was normally distributed around a mean (skewness=−0.01±0.24, kurtosis=−0.09±0.48) with a mean of 110.6 mV/Gy, with a standard deviation of 2.4% at 0.86 Gy. The standard deviation of readings(More)