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In this article, we have described a computational framework for multiscale simulation of gas flow in subject-specific airway models of the human lung. The framework consists of five major components: accurate extraction of airway geometry from MDCT image data sets, geometrical modeling of airway trees, novel 3-D and 1-D coupled mesh generation, 3-D(More)
We have developed an image-based computational model of blood flow within the human pulmonary circulation in order to investigate the distribution of flow under various conditions of posture and gravity. Geometric models of the lobar surfaces and largest arterial and venous vessels were derived from multi-detector row X-ray computed tomography. The(More)
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