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Two stimuli that have been associated with nutrient remobilization in plants are phosphate (P(i)) starvation and senescence. Little is known about how the nutrient remobilization machinery is induced at the molecular level, but in the case of P(i) starvation, ribonucleases are considered to play important roles in the remobilization process. Here, the(More)
This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m (100 mCi) [C]CPT-11 in eight patients with solid tumors. Mean 6 S.D. recovery of radioactivity in urine and feces was 95.8 6 2.7% (range 92.2–100.3%, n 5 7) of dose. Radioactivity in blood, plasma, urine, and feces was determined for at(More)
This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100 microCi) [(14)C]CPT-11 in eight patients with solid tumors. Mean +/- S.D. recovery of radioactivity in urine and feces was 95.8 +/- 2.7% (range 92.2-100.3%, n = 7) of dose. Radioactivity in blood, plasma, urine, and feces was(More)
U-74006F, 21-(4-(2,6-dipyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16 alpha-methylpregan-1,4,9(11)-triene monomethane sulfonate, is currently under development for the treatment of human central nervous system trauma and ischemia. The iv pharmacokinetics and excretion of 14CU-74006F (labeled in the 16 alpha-methyl group) and 3HU-74006F (labeled in a(More)
Prostaglandin E1 (PGE1) was administered intravenously to conscious beagles and the plasma concentrations of its pulmonary metabolite 13,14-dihydro-15-keto-PGE1 were quantitated at various times after dosing. Pharmacokinetic parameters were calculated for four experimental designs including single-dose bolus injections (30, 10, and 3 micrograms PGE1/kg):(More)
The peripheral plasma content of the pulmonary metabolite, 13,14-dihydro-15-keto-prostaglandin E2, reflects prostaglandin E2 (PGE2) biosynthesis and disposition in vivo more reliably than the peripheral plasma content of PGE2 itself. However, the chemical instability of 13,14-dihydro-15-keto-PGE2 and the multiple fates of its degradation products hinder the(More)
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