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Nuclear receptors modulate the transcription of genes in direct response to small lipophilic ligands. Binding to ligands induces conformational changes in the nuclear receptors that enable the receptors to interact with several types of cofactor that are critical for transcription activation (transactivation). We previously described a distinct set of(More)
The dimeric intracellular subtilisin proteases (ISPs) found throughout Gram-positive bacteria are a structurally distinct class of the subtilase family. Unlike the vast majority of subtilisin-like proteases, the ISPs function exclusively within the cell, contributing the majority of observed cellular proteolytic activity. Given that they are active within(More)
This paper describes the design and delivery of a new course introducing the joint topics of enterprise integration and enterprise architecture. Planned for an Information Technology curriculum, the course sits at the crossroads of Computer Science and Information Systems and is intended for upper level undergraduate and graduate students pursuing degrees(More)
Increasing integration services can improve opportunistic development by presenting monolith applications as opportunities for mashups. O pportunities are available resources that yield desired results. Their suitability depends on who seizes the opportunity and the context for its use. Opportu-nistic development relies on the availability of reusable(More)
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