M. T. F. Caramés

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BACKGROUND Glutathione has been implicated in growth factor-mediated chemoresistance of colon cancer cells. MATERIALS AND METHODS We evaluated the influence of hepatocyte growth factor, vascular endothelial growth factor and epidermal growth factor on the effect of 5-fluorouracil, oxaliplatin and SN-38 (the active metabolite of irinotecan) on WiDr cells.(More)
BACKGROUND A common cause of treatment failure in colorectal cancer is chemoresistance, which may be related to the redox state of cancer cells and the tumour microenvironment, where growth factors (GFs) play an important role. Glutathione (GSH), a key regulator of the redox balance, is involved in GF signalling systems and may also protect against(More)
In this communication we show how different innovative teaching practices have been implemented in lab matters. In order to make the most of lab work we have adopted different pedagogical approaches which combine traditional and innovative activities and resources. Pre-lab activities (seminars, simulations, self assessment tasks, videos) have being designed(More)
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