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Alzheimer's disease (AD) is characterized by the deposition in brain of beta-amyloid (Abeta) peptides, elevated brain caspase-3, and systemic deficiency of cytochrome c oxidase. Although increased Abeta deposition can result from mutations in amyloid precursor protein or presenilin genes, the cause of increased Abeta deposition in sporadic AD is unknown.(More)
A 120 MeV, 2856 MHz, TW linac, with a microwave gun, alpha magnet, and chopper, has been built at SSRL as a preinjector for and along with a 3 GeV booster synchrotron ring. The resulting injector will be available on demand to fill SPEAR, which is a storage ring now dedicated to synchrotron light production. The linac sections were purchased from China, the(More)
We created and studied new cybrid cell lines from sporadic Alzheimer's disease (SAD) or control (CTL) subjects to assess mitochondrial abnormalities just after metabolic selection ("early passage") and again six passages later ("late passage"). Cytochrome oxidase (CO) activities in early passage SAD cybrids created independently from the same platelet(More)
  • LIGHT SOURCE, M. Borland, +5 authors M. Woodley
  • 2001
The Linac Coherent Light Source (LCLS) is a fourth-generation light source demonstration project based on the self-amplified spontaneous emission (SASE) free-electron laser (FEL) concept. It will combine a new photoinjector, the Stanford Linear Accelerator Center (SLAC) linac, with two stages of bunch compression and a long undulator to create intense(More)
Recently, we have explored application to the Advanced Photon Source (APS) of Zholents'[1] crab cavity scheme for production of short x-ray pulses. We assumed use of superconducting (SC) cavities in order to have a continuous stream of crabbed bunches and flexibility of operating modes. The challenges of the SC approach are related to the size, cost, and(More)
The high quality LCLS electron beam generated in the photoinjector is subject to many insta-bilities in the downstream acceleration and compression. The instability can be initiated by any density modulation of the electron beam generated at the photocathode. In this paper, we prescribe the tolerance on the initial electron beam density modulation possibly(More)
We describe use of the Advanced Photon Source (APS) rf thermionic gun [1], alpha-magnet beamline, and linac [2] to produce a stable high-brightness beam in excess of 100 amperes peak current with normalized emittance of 10 π mm-mrad. To obtain peak currents greater than 100 amperes, the rf gun system must be tuned to produce a FWHM bunch length on the order(More)