M Szikszay

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We used the autoradiographic 2-deoxy-D-[1-14C]glucose (14C-DG) method of Sokoloff to identify brain areas with altered rates of local cerebral glucose utilization (LCGU) in vivo in response to peripheral I-nicotine administration (0.1, 0.3, 1.0, and 1.75 mg/kg, s.c.). Nicotine stimulated LCGU primarily in areas reported to contain nicotine binding sites,(More)
The autoradiographic 2-deoxy-D-[1-14C]glucose method was used to map the effect of subacute capsaicin administration on local cerebral glucose utilization, an index of brain function. After treatment with an 80 mg/kg, subcutaneous, cumulative dose of capsaicin over 3 days, a challenge dose of 20 mg/kg capsaicin stimulated glucose utilization in dorsal(More)
The autoradiographic 2-deoxy-D-[1-(-14)C]glucose ([14C]2-DG) method was used to map the effects of subcutaneous (s.c.) morphine (8.0 mg/kg), oxymorphone (0.4 mg/kg) and nalbuphine (16.0 mg/kg) on local cerebral glucose utilization (LCGU), an index of local brain function. At the dosages administered, effects of the opioid agonists on LCGU were very(More)
The autoradiographic 2-deoxy-D-[1-14C]glucose ([14-C]DG) method was used to map the effects of morphine, oxymorphone and nalbuphine on local cerebral glucose utilization (LCGU), an index of local brain function. The mu agonists (morphine, oxymorphone) decreased LCGU in thalamic nuclei, including some which have been implicated in somatosensory processing.(More)
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