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Glutamate-induced excitotoxicity and oxidative damage are believed to play an important role in the development of a number of central nerve system disorders. Nuclear-factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of many cytoprotective genes.We report herein that 5,6-dihydrocyclopenta-1,2-dithiole-3-thione (CPDT), which(More)
Sulfur, as a macronutrient, is essential for all kinds of organisms. Sulfate, the primary available source of sulfur, is firstly activated by adenylation catalyzed by ATP sulfurylase (ATPS) to form adenosine 5′-phosphosulfate (APS), which will be further phosphorylated into 3′-phosphoadenosine 5′-phosphosulfate (PAPS) by APS kinase (APSK). In some(More)
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