M. Steurer

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BACKGROUND Circulating endothelial cells (CEC) and endothelial precursor cells (CEP) have been suggested as markers for angiogenesis in cancer. However, CEC/CEP represent a tiny and heterogeneous cell population, rendering a standardized monitoring in peripheral blood difficult. Thus, we investigated whether a PCR-based detection method of CEC/CEP might(More)
BACKGROUND The murine homologue of human vasohibin (mVASH1), a putative antiangiogenic protein, was investigated for its effects on in vitro and in vivo angiogenesis. METHODS Cell growth and migration were analyzed in murine fibroblasts, smooth muscle cells and endothelial cells. Angiogenic sprouting was studied in human umbilical vein endothelial cells(More)
—Although many attempts have been made to design a fault-current limiting (FCL) circuit breaker (FCLCB) for medium voltage electric power systems, no economically attractive solution has been achieved so far. In this paper, a novel concept for a FCLCB is introduced based on a hybrid arrangement of semiconductors , temperature-dependent resistors, and a(More)
  • Walter HOLAUS, Charles Sigrist, Heiko Vögeli, Michael Steurer, Manfred Grader, Elida Muminovic +4 others
  • 2001
ii iii Acknowledgements This work formed from 1997 to 2001 during my work as a doctoral candidate at the Swiss Federal Institute of Technology in Zurich. I would first like to thank Prof. Dr. Klaus Fröhlich for giving me the opportunity to pursue an uncommon idea and for his continuing support and valuable input during the work. Many thanks also to Prof.(More)
We report a 48-year-old woman with a pleural pseudoneoplasm requiring different diagnostic and therapeutic strategies. After initial presentation with increasing dyspnoea, temperature, dry cough, and interscapular pain diagnostic processing showed a large mediastinal mass with marked pleural effusion and high metabolic activity in the 18F-FDG-PET/CT.(More)
Classic hairy cell leukemia (HCL) is a rare indolent B-cell-lymphoproliferative disorder, first described as a distinct disease entity in 1958. After more than two decades without effective chemotherapeutic options and a dismal prognosis of less than 5 years, only the introduction of interferon-α (IFN-α) allowed for response rates between 80–90 % and(More)
The purpose of this study was to evaluate the extent of constitutive activity among orphan class-A G protein coupled receptors within the cAMP signaling pathway. Constitutive signaling was revealed by changes in gene expression under control of the cAMP response element. Gene expression was measured in Chinese hamster ovary cells transiently co-transfected(More)
Iron deficiency and iron deficiency-associated anemia are common complications in cancer patients. Most iron deficient cancer patients present with functional iron deficiency (FID), a status with adequate storage iron, but insufficient iron supply for erythroblasts and other iron dependent tissues. FID is the consequence of the cancer-associated cytokine(More)
Exome sequencing of primary tumors identifies complex somatic mutation patterns. Assignment of relevance of individual somatic mutations is difficult and poses the next challenge for interpretation of next generation sequencing data. Here we present an approach how exome sequencing in combination with SNP microarray data may identify targets of chromosomal(More)
INTRODUCTION Polyarteritis nodosa (PAN) is a necrotizing vasculitis of small to-medium-sized vessels, rarely associated with hematologic neoplasms. CASE REPORT We report a 44-year-old man with a history of monoclonal gammopathy of undetermined significance (MGUS) who presented with rapidly progressing sensorimotor peripheral neuropathy. Two weeks after(More)