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Memory T-cells promote allograft rejection particularly in costimulation blockade (CoB)-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (LFA3-Ig) selectively eliminates memory T-cells and when combined with a CoB-based regimen utilizing CTLA4-Ig, prevents renal allograft rejection and alloantibody formation in(More)
Process mining techniques have been used to analyze event logs from information systems in order to derive useful patterns. However, in the big data era, real-life event logs are huge, unstructured, and complex so that traditional process mining techniques have difficulties in the analysis of big logs. To reduce the complexity during the analysis, trace(More)
In this paper, we present a Web Ontology language (OWL) -based spatio-temporal data model that introduces the 'spatio-temporal coordinate' concept and makes use of 'temporal lifting'. The ontology-based data model captures application data features. A process for application data model development that incorporates spatio-temporal dependencies is presented.(More)
This experiment was conducted to investigate the effects of palm kernel expellers on productive performance, nutrient digestibility, and changes in white blood cells (WBC) of lactating sows. A total of 14 sows (200±12 kg of average body weight [BW]; 2.5 of average parity) were used and moved from gestation room to farrowing room on d 109 of gestation. Sows(More)
The adaptive potential of populations and therefore their ability to cope with rapid environmental changes is a question of paramount fundamental and applied importance. However, what is still not clear is the effect of population position within the species range (i.e. core vs. edge) on population adaptive potential, and whether the adaptive potential can(More)
This experiment was conducted to investigate the effects of palm kernel expellers on growth performance, nutrient digestibility, and blood profiles of weaned pigs. A total of 88 weaned pigs (6.94±0.76 kg body weight [BW]; 28 d old) were randomly allotted to 2 dietary treatments (4 pigs/pen; 11 replicates/treatment) in a randomized complete block design (sex(More)