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We have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus macaques (Macaca mulatta) against infection with virulent L. (L.) major. Positive antigen-specific recall(More)
Visceral leishmaniasis (VL) was experimentally induced in rhesus macaques (Macaca mulatta) by intravenously inoculating 2 x 10(7)amastigotes/kg of body weight of Leishmania infantum. The macaques developed a systemic disease showing characteristic features of human VL such as fever, diarrhoea, body weight loss, anaemia, hypergammaglobulinaemia and transient(More)
Based on a general methodology using natural coordinates , a three-dimensional whole body response model for the articulated human body is presented in this paper. The joints between biomechanical segments are defined by forcing adjacent bodies to share common points and vectors that are used in their definition. A realistic relative range of motion for the(More)
A fully integrated switchable dual-band low-noise amplifier (DB-LNA) for 802.11b/g and WiMAX applications is presented. By using switch effective inductance technique for the input matching network (IMN) and a switched LC tank to tune the amplifier gain, dual-band operation for 2.4 GHz and 3.5 GHz bands is achieved. Using a standard 0.18um CMOS process, a(More)
We measure and model the steady transport of specific conductivity and dissolved oxygen through a groundwater plume from a highway infiltration basin in southeastern Massachusetts. Specific conductivity is treated as a conservative surrogate for runoff contamination , and the data calibrate a 0.27-m vertical dispersivity ␣ of the aquifer and the bottom(More)
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