M. Sherwan Muhyaddin

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1 The effects of gamma-aminobutyric acid (GABA) and related drugs on the isolated anococcygeus muscle of the rat were determined. 2 GABA caused a dose-related inhibition of the electrically-evoked twitch response. 3 The maximum response to GABA was a 56.8% depression of twitch response, with an EC50 of 0.68 microM. 4 (+/-)-Baclofen mimicked the effect of(More)
The release of preaccumulated [3H]noradrenaline from the isolated rat anococcygeus muscle, a tissue endowed with a rich noradrenergic innervation, was investigated. Field stimulation produced a marked, calcium-dependent enhancement in release, which could be substantially inhibited by the inclusion of low concentrations of GABA or (-)-baclofen (but not the(More)
Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 cells have some gene profile similarity(More)
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