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Two-dimensional echocardiographic methods of left ventricular volume computation are limited by geometric assumptions and image plane positioning error in the nonvisualized dimension. We evaluated a three-dimensional (3D echocardiographic method that addresses these limitations. Our method uses a volume computation algorithm based on polyhedral surface(More)
Atmospheric Chemistry and Physics Discussions This discussion paper is/has been under review for the journal Atmospheric Chemistry and Physics (ACP). Please refer to the corresponding final paper in ACP if available. Abstract In this study, the Community Multiscale Air Quality (CMAQ) modeling system is used to simulate the ozone (O 3) episodes during the(More)
BACKGROUND Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively activated IFN/STAT1 pathway suggest an association with an aggressive tumor phenotype. We hypothesized that tumor clones that constitutively overexpress this pathway are preferentially(More)
Ultrasound images may be difficult to interpret because of the lack of an image orientation display. To resolve this problem, a three-dimensional (3-D) ultrasound scanner has been constructed that provides spatial registration and display of position and orientation of real-time images while allowing unconstrained movement of the scanning transducer. It(More)
We report the anticarcinogenic, anti-aging polyphenol resveratrol activates the radio- and chemo-inducible cancer gene therapy vector Ad.Egr.TNF, a replication-deficient adenovirus that expresses human tumor necrosis factor alpha (TNF-alpha) under control of the Egr-1 promoter. Like ionizing radiation or chemotherapeutic agents previously shown to activate(More)
We have constructed a three-dimensional (3-D) ultrasound scanner to make examinations easier and more accurate. The accuracy of the 3-D scanner has been determined by scanning a three-dimensional model. Lengths, angles, and volume of the model were computed and compared to values determined from physical measurement. Distances between image planes were(More)
Deltagamma(1)34.5 mutant herpes simplex type 1 viruses are under active clinical investigation as oncolytic therapy for cancer. Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) activity has been shown to suppress protein kinase R and thereby confer oncolytic susceptibility to some human tumors by R3616, a virus deleted for(More)
Oxygenated volatile organic compounds (OVOCs) are important products of the photo-oxidation of hydrocarbons. They influence the oxidizing capacity and the ozone-forming potential of the atmosphere. In the summer of 2008, 2 months of emission restrictions were enforced in Beijing to improve air quality during the Olympic Games. Observational evidence(More)
Oncolytic viruses have been combined with standard cancer therapies to increase therapeutic efficacy. Given the sequential activation of herpes viral genes (herpes simplex virus-1, HSV-1) and the temporal cellular changes induced by ionizing radiation, we hypothesized an optimal temporal sequence existed in combining oncolytic HSV-1 with ionizing radiation.(More)