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We investigated the inhibitory effects of aurochloric acid (AuCl4H) on reverse transcriptase (RT) derived from avian myeloblastosis virus and DNA polymerase alpha (pol. alpha) purified from HeLa S3 cells. The activities of RT, pol. alpha and E. coli DNA polymerase I (pol. I) with dTTP as the substrate were inhibited 50% at AuCl4H concentrations of 18(More)
To determine the relationship between protein kinase C and the promotion of carcinogenesis, we investigated the effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells. Diacylglycerols, which are activators, and specific inhibitors, such as palmitoyl-DL-carnitine chloride (PC),(More)
To discover the relationship between the activation of protein kinase C and the generation of reactive oxygen in the tumor promotion process, we investigated the effects of radical scavengers on diacylglycerol-promoted transformation in BALB/3T3 cells. Superoxide dismutase (SOD) showed inhibitory effects on both 1-oleoyl-2-acetylglycerol (OAG)-promoted and(More)
In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inhibited TPA-promoted transformation in a(More)
The effects of some inhibitors of phospholipid metabolism were studied using a two-stage transformation assay system in vitro with 3-methylcholanthrene (3-MC) initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion in BALB/3T3 cells. Inhibitors of phospholipid metabolism such as hydrocortisone (HC), p-bromophenacyl bromide (BPB),(More)
To find the mechanism of promotion process, we have investigated the antipromoting effects of radical scavengers and specific inhibitors for phospholipid metabolism and for protein kinase C using a two-stage transformation assay system in BALB/3T3 cells. All radical scavengers and inhibitors tested showed the antipromoting effects on(More)
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