M. Schubert

L. Moll2
W. Krone2
S. Freude2
O. Stöhr2
2L. Moll
2W. Krone
2S. Freude
2O. Stöhr
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The role of mitochondrial dysfunction in the development of insulin resistance and type 2 diabetes remains controversial. In order to specifically define the relationship between insulin receptor (InsR) signaling, insulin resistance, hyperglycemia, hyperlipidemia and mitochondrial function, we analyzed mitochondrial performance of insulin-sensitive,(More)
  • J. Zemva, M. Udelhoven, L. Moll, S. Freude, O. Stöhr, H. S. Brönneke +3 others
  • 2012
The insulin receptor substrates (IRS) are adapter proteins mediating insulin's and IGF1's intracellular effects. Recent data suggest that IRS2 in the central nervous system (CNS) is involved in regulating fuel metabolism as well as memory formation. The present study aims to specifically define the role of chronically increased IRS2-mediated signal(More)
INTRODUCTION Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the dynamics of changes on the molecular level. IMAGING OF AD(More)
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