M. Sakurai

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Somatic mutation of ten-eleven translocation 2 (TET2) gene is frequently found in human myeloid malignancies. Recent reports showed that loss of Tet2 led to pleiotropic hematopoietic abnormalities including increased competitive repopulating capacity of bone marrow (BM) HSCs and myeloid transformation. However, precise impact of Tet2 loss on the function of(More)
ALTHOUGH considerable progress has been made in the heterotransplantation of various human tumours into nude mice (Rygaard and Povlsen, 1969; kSchmidt and G:ood, 1975; Ueyama et al., 1975), the growth of human myelogenous leukaemic cells has not yet been reported, except for a tissue culture line (Lozzio, Lozzio and Machado, 1976). This paper reports the(More)
Purpose Tyrosine kinase inhibitors (TKIs) have improved overall survival of patients with chronic myeloid leukemia (CML). Moreover, it has been reported that some of the patients achieve treatment-free remission (TFR) after cessation of TKIs, even though leukemic stem cells (LSC) of CML are considered to be resistant to TKIs. Therefore, these findings(More)
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