M. Sakurai

Y. Komada2
M. Ido2
Y. Kaneko1
N. Maseki1
2Y. Komada
2M. Ido
1Y. Kaneko
1N. Maseki
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The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82 months. Microvessels were identified by immunohistochemical staining for factor VIII-related antigen in formalin-fixed, paraffin-embedded primary(More)
ALTHOUGH considerable progress has been made in the heterotransplantation of various human tumours into nude mice (Rygaard and Povlsen, 1969; kSchmidt and G:ood, 1975; Ueyama et al., 1975), the growth of human myelogenous leukaemic cells has not yet been reported, except for a tissue culture line (Lozzio, Lozzio and Machado, 1976). This paper reports the(More)
Tumour necrosis factor (TNF)-alpha induces apoptosis in a human acute myeloid leukaemia cell line, Kasumi-1. To examine the role of protein phosphorylation in signal transduction of TNF-alpha-induced apoptosis, a variant cell line resistant to TNF-alpha was established by an intermittent challenge of Kasumi-1 cells with increasing concentrations of(More)
In a study of 154 neuroblastomas, loss of heterozygosity (LOH) was observed on 1p (13%, 19/143), 11q (19%, 11/59), 14q (15%, 15/97), 17p (5%, 5/105) and 17q (17%, 9/52). We also found an increase in NM23H1 copy number in 14% (13/95) of neuroblastomas. All except one tumour with an increased copy number stained positive with anti-NM23H1 monoclonal antibody.(More)
The effects of N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on the growth of P388 and its multidrug-resistant (MDR) variants were examined with the objective of assessing the possible changes in cyclic nucleotide-dependent protein kinases and protein kinase C-mediated pathways associated(More)
Neuroblastoma (NB) cells possess morphological and biological properties in vivo and in vitro, the cell type having the characteristics of primitive 1981). NB cell lines established in vitro have been shown to consist of two morphologically distinct types of cells: neuroblast-like and epithelial-like These two cell types can undergo bidirectional phenotypic(More)
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