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Air breathing, especially oxygen therapy, exposes the lung to reactive oxygen species (ROS). Antioxidant enzymes (AOEs) may protect the lung from ROS-mediated injury. Because expression of the key AOEs increases in several animal species during gestation, we investigated (1) the messenger RNA (mRNA) and activity levels of the key AOEs manganese and(More)
SUMMARY Oxidative stress has been increasingly implicated in the pathogenesis of lung diseases. Antioxidant mechanisms and their regulation are poorly characterized in the human lung, but they may be important in the development and progression of pulmonary diseases. The present study was designed to investigate the regulation of the most important(More)
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