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Ethylene oxide (EtO) is an alkylating agent and a model direct-acting mutagen and carcinogen. This study has evaluated a panel of biologic markers including EtO-hemoglobin adducts (EtO-Hb), sister-chromatid exchanges (SCEs), micronuclei, chromosomal aberrations (CAs), DNA single-strand breaks (SSB) and an index of DNA repair (ratio of UDS to NA-AAF-DNA(More)
Complete heart block developed during HBE studies in a patient with left bundle branch block, after inadvertent catheter-induced trauma to the right bundle branch. Normal intraventricular conduction (HV interval) was documented during the initial part of the study, and was demonstrated to be markedly prolonged after the appearance of heart block. Conduction(More)