M S Poliak

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The possibility of using 2 variants of a unified nutrient medium containing no Hottinger's broth for determination of the biological activity of a large number of antibacterial antibiotics was shown. The medium provided satisfactory reproducibility of the results. It contained yeast extract as a source of nitrogen. The medium was selected with the method of(More)
On diffusion of an antibiotic from the disk to the nutrient medium, gel concentration of an antibiotic changes. This process is individual for each antibiotic. The action of different concentrations of the antibiotic at different intervals results in the suppression of microbial growth around the disk (formation of a zone). The relationship between the(More)
The procedure for investigation of the inhibition growth zone formation on diffusion of polyenic antibiotics into inoculated gel is presented. The model of strong inactivation is applicable when the drug inactivation is significant during the period of the zone formation and not only during the period of the 2-fold increasing of the number of the test(More)
The process of inhibition growth zone formation due to diffusion of polyenic antibiotics into inoculated gel was studied. Variability of the zone size with time was traced as a continuation of the mathematical model of zone formation described earlier. Differences in the zone size variability are shown in case the drug inactivation level is so low that it(More)