M. S. Gel'fand

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EDAS, a database of alternatively spliced human genes, contains data on the alignment of proteins, mRNAs, and EST. It contains information on all exons and introns observed, as well as elementary alternatives formed from them. The database makes it possible to filter the output data by changing the cut-off threshold by the significance level. The database(More)
The conservation of alternative splicing in orthologous genes from the human and mouse genomes was analyzed. Alternatively spliced mouse genes from the AsMamDB database were used to scan the draft human genome. The mouse protein isoforms were aligned with respect to orthologous human genes, and thus the exon-intron structure of the latter was established.(More)
Comparative approach to computer analysis of regulatory signals allows one to predict new signals in bacterial genomes with high accuracy. A prediction is reliable whenever candidate signals are consistently observed in several related genomes. We applied comparative approach to the analysis of the Fnr regulon of gamma-proteobacteria. Responding to changes(More)
Bacteriocin production in many Gram-positive bacteria is controlled by a two-component regulatory system that is composed of the sensor protein and the response regulator. In this work, methods of computer analysis were used to describe the locus of genes responsible for the synthesis of class II bacteriocins in the Streptococcus equi genome. Potential(More)
One of the main trends in the prokaryote genomics is the comparative analysis of metabolic pathways. This method can be used for the analysis of experimentally studied systems of co-regulated genes, as well as genes with unknown regulatory signals. In this study we apply the comparative analysis of regulatory signals to the genes of the enzymes for fatty(More)
Comparative computer-assisted analysis was used to study putative GlpR-regulons responsible for metabolism of glycerol and glycerol-3-phosphate in genomes of alpha-, beta-, and gamma-proteobacteria. New palindromic GlpR-binding signals were identified in gamma-proteobacteria; consensus sequences being TGTTCGATAACGAACA for Enterobacteriaceae,(More)