Learn More
BACKGROUND Epidemiologic data on human T-lymphotropic virus type I (HTLV-I) in Guadeloupe (French West Indies) are scant. STUDY DESIGN AND METHODS From January 1989 to December 1996, 59,426 blood donors were screened by enzyme immunoassay for antibodies to HTLV-I. All repeatedly reactive samples were confirmed by Western blot. Temporal trends in HTLV-I(More)
There is known to be a significant correlation between the number of glucocorticoid receptors in tissues and their anti-inflammatory effect. In this work, the specific binding of glucocorticoids was studied in inflammatory fibroblasts. Human fibroblasts were obtained from the knee joint of a rheumatoid patient undergoing surgery; experimental fibroblasts(More)
Title of Document: WHEN DO TARGETS’ PAST FINANCIAL RESULTS MATTER MOST TO ACQUIRERS? THE ROLE OF DISRUPTION OF TARGETS’ EXISTING OPERATIONS MaryJane R. Rabier, Ph.D. Candidate 2014 Directed By: Professor Michael Kimbrough Department of Accounting and Information Assurance Robert H. Smith School of Business This study examines how anticipated disruption in(More)
Continuous delivery of factor VIII (FVIII) protein in hemophiliacs by gene therapy will represent a major clinical advance over the current practice of infrequent administration of purified FVIII. Conceptually, retroviral vectors that can permanently insert the FVIII gene into the DNA of the host cell appear the most suitable vehicles for this specific(More)
Glucocorticoids (GS) are potent anti-inflammatory agents used in the treatment of rheumatoid arthritis (RA). These steroids exert their activity on target cells by interaction with a high affinity binding protein. Fibroblasts from both quiescent and inflammatory tissues contain glucocorticoid receptors and a significant correlation exists between the number(More)
Specific receptors for [3H]-15 HETE have been identified on GH3 cells, a cloned strain of rat pituitary cells. With incremental inputs of radioligand and a constant cell number, specific [3H]-15 HETE binding reached a plateau indicative of saturable binding sites. Ligand analysis of the Scatchard plot demonstrated a single class of high affinity binding(More)
Circulating human polymorphonuclear neutrophils are involved in asthma after their migration into the lung by local chemotactic factors. Investigation of the locomotion of neutrophils in Boyden chambers, showed that the chemotactic intensity of the platelet-activating factor (PAF) was similar in cells from healthy subjects and allergic asthmatics, although(More)