M R Lauricella

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Evidence exists supporting an important role for insulin-like growth factors (IGFs) during fetal growth. In the present report we performed studies to define whether developing chick retina contains IGFs and whether IGFs play a role in the growth of this tissue. We have shown that both IGF-I and IGF-II are present in chick embryo retina throughout(More)
The nonlinear relation between stimulus intensity and response amplitude of the electroretinogram (ERG) scotopic b wave can be described by a curve based on the Naka-Rushton (NR) equation. Up to now, the NR equation has been used to assess the features of the normal and pathological ERG, but the best approach for a correct evaluation of the parameters is(More)
In this paper we study the development of chick embryo retina cultured in vitro and the effects exerted by insulin. Retinas were removed from 7-day embryos and cultured in serum- and hormone-free medium for 7 additional days. Under these conditions retinal cells survived and underwent cholinergic differentiation, as previously ascertained by Hausman et al.(More)
New possible causes and unexplored aspects of the electroretinogram were evaluated in a case of vitamin A deficiency secondary to surgical therapy for morbid obesity. The Naka-Rushton equation, applied to the scotopic b-wave, demonstrated the quantal catch reduction caused by the loss of rhodopsin in the outer segment of photoreceptors. Study of the Fourier(More)
The alterations of the inner retina in retinitis pigmentosa have been described in previous papers less often than the external retina alterations, both from the electrophysiological and morphological point of view. The oscillatory potentials (OPs) of the electroretinogram (ERG) are a good tool to investigate the inner part of the retina because of the deep(More)
PURPOSE To examine the apoptotic effect induced in human retinoblastoma Y79 cells by camptothecin, etoposide, and amsacrine, to examine the effect of these drugs on the expression of many apoptosis-related modulators, and to test the antiapoptotic effect exerted by insulin-like growth factor-I (IGF-I). METHODS Morphologic features of apoptosis were(More)
Triple-negative breast cancers (TNBCs) are clinically aggressive forms associated with a poor prognosis. We evaluated the cytotoxic effect exerted on triple-negative MDA-MB231 breast cancer cells both by parthenolide and its soluble analogue dimethylamino parthenolide (DMAPT) and explored the underlying molecular mechanism. The drugs induced a dose- and(More)
Retinas of chick embryos contain insulin and further, are capable of synthesizing it, as demonstrated by incubating retinas at different ages (7th-18th day) with [3H]leucine. The synthesized radioactive insulin was isolated and assayed by means of a HPLC procedure. The synthesis of insulin was found to be highest in the youngest retinas studied (day 7),(More)
The visual evoked potentials (VEPs) elicited by pattern stimulation were studied in a group of 62 type I insulin-dependent diabetics. The patients did not have retinopathy. An attempt was made to correlate the duration of the diabetes, insulin requirement, blood glucose and glycosylated hemoglobin with the VEPs. Our study showed that the VEPs of the(More)
Electrospinning is an nanotechnology process whereby an external electric field is used to accelerate and stretch a charged polymer jet, so as to produce fibers at nanoscale diameters. In quest of a further reduction in the cross section of electrified jets hence of the resulting electrospun fibers, we explore the effects of an external rotating electric(More)