M R Lail-Trecker

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OBJECTIVE To review data regarding the expression, function, and signal transduction pathways associated with hepatocyte growth factor/scatter factor (HGF/SF) as related to normal and neoplastic cells of reproductive tissues. METHODS Studies involving HGF/SF were reviewed and the data were summarized. RESULTS Hepatocyte growth factor/scatter factor is(More)
The ability of the estrogen receptor signaling pathway to regulate cell-cell adhesion, and N-cadherin and beta-catenin expression was examined in rat somatolactotropic GH3 cells cultured in serum-free, phenol red-free medium (SFM). Estradiol-17beta (E2) promoted a nonadherent phenotype, whereas the steroidal antiestrogen, ICI 182,780, induced the formation(More)
The present studies revealed that hepatocyte growth factor (HGF) disrupts cell contact, increases both type 3 IP3 receptor and intracellular calcium ([Ca2+]i) levels and induces apoptosis of rat ovarian surface epithelial cells (ROSE-179 cells). Type 3 IP3 receptor was only increased in cells that lost cell contact. Disrupting cell contact by depleting(More)
Previous observations that extracellular calcium (Ca2+) enhanced PRL mRNA levels posttranscriptionally in GH3 rat pituitary tumor cells were made using double-stranded transcription probes. The effects of Ca2+ and the Ca2+ ionophore, ionomycin, on PRL gene expression in GH3 and 235-1 cells were investigated using site- and strand-specific probes. Treatment(More)
We have investigated a role for calcium-dependent cell-cell adhesion in the regulation of prolactin gene expression in rat pituitary GH(3) cells. Cells cultured in a calcium-free, serum-free medium (SFM) express low levels of prolactin and growth hormone mRNA. As expected, addition of 0.5 mM CaCl(2) to GH(3) cells in SFM produced a specific, severalfold(More)
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