Learn More
Each organelle of the secretory pathway is required to selectively allow transit of newly synthesized secretory and plasma membrane proteins and also to maintain a unique set of resident proteins that define its structural and functional properties. In the case of the endoplasmic reticulum (ER), residency is achieved in two ways: (a) prevention of residents(More)
Stereological methods have been applied to a cross-sectional sample of human placentae collected at 10-41 weeks of gestation in order to provide a quantitative description of the growth and maturation of villi. Random tissue sections were analysed to derive volumes, surface areas, lengths, diameters and membrane thicknesses for villi and their fetal(More)
Random tissue sections of placentae from control and diabetic deliveries were analysed stereologically. The aim was to test whether or not adaptations in oxygen diffusive conductances occur to help compensate for fetal hypoxic stress in utero. Organs were from 34 control and 55 diabetic deliveries (39 from White's classes A, B, C and 16 from classes D, F/R)(More)
Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were recorded and placentae sampled in a(More)
Stereological methods were used to test whether or not altitudinal, ethnic and sex differences in birthweight in Bolivia are associated with differences in placental morphology. Estimates of the volumes, surface areas, lengths and diameters of villi and of fetal capillaries were obtained by analysing paraffin sections of tissue. The average highland(More)
A combination of stereological and physicochemical data was used to estimate the oxygen-diffusing capacity of the human term placenta. The effects on this morphometric diffusing capacity of isolated changes in placental structure were investigated by permitting volumes, surface areas and harmonic mean diffusion distances to deviate from normal baseline(More)
The contribution made by fetal capillary peripheralization to the thinning of the villous membrane seen in human placentae from high-altitude pregnancies is examined by stereological methods. Variables characterizing the shape of the villous core and the spatial relationships between trophoblast and capillaries are quantified. They shed light on the(More)
Point counting volumetry has been used to decide whether or not altitudinal, ethnic and sex differences in birth weight in Bolivia are accompanied by changes in placental composition. Sixty eight placentae from healthy, term pregnancies were sampled from populations of Amerindian and non-Indian women living in Santa Cruz (400 m) and La Paz (3600 m).(More)
This review highlights recent progress in the development of anticancer radiopharmaceuticals. Molecularly targeted radiotherapy refers to the selective delivery of radionuclides that emit charged particles, such as α particles, β or Auger electrons, to cancer cells via a targeting vector. The discovery of new molecular targets through systems biology and(More)
A morphometric model of oxygen diffusion is employed to calculate the partial, total and specific conductances of human placentae from low- and high-altitude term pregnancies. Placentae were obtained from indigenous and non-indigenous populations and the diffusion pathway dissected into six tissue compartments. Birthweights were reduced at high altitude but(More)