M R Escorbar

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Transport of the achiral cationic drug amantadine by purified renal cortical rat tubules was investigated in bicarbonate [Krebs-Henseleit solution (KHS)] and nonbicarbonate buffers. Values of the apparent Km for amantadine accumulation were higher (P < .001, mean +/- S.E., n = 5) for all nonbicarbonate buffers compared with those in KHS in both proximal (76(More)
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