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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.

• Joern E Schmitz, Marcelo J. Kuroda, +13 authors Keith A Reimann
• Science
• 1999

Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the… (More)

A nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody.

• Joern E Schmitz, Meredith A. Simon, +11 authors Keith A Reimann
• The American journal of pathology
• 1999

Nonhuman primates provide valuable animal models for human diseases. However, studies assessing the role of cell-mediated immune responses have been difficult to perform in nonhuman primates. We have… (More)

High-level expression and characterization of a mouse-human chimeric CD4 antibody with therapeutic potential.

• J. E. Looney, David M. Knight, +7 authors John Ghrayeb
• Human antibodies and hybridomas
• 1992

The use of murine anti-CD4 monoclonal antibodies (MAbs) has shown considerable promise for the treatment of allograft rejection and rheumatoid arthritis. We have constructed mouse-human anti-CD4… (More)

Antilipid A monoclonal antibody HA-1A decreases the capacity of bacterial lipopolysaccharide to activate human vascular endothelial cells by an immune adherence mechanism.

• E M Paleolog, Peter D Katsikis, +5 authors Marc Feldmann
• Cytokine
• 1993

Human monoclonal IgM antibody HA-1A, which recognizes the lipid A component of bacterial lipopolysaccharide (LPS), has been shown to reduce mortality in Gram negative septicemia. The vascular… (More)

Human-murine chimeric CD4 monoclonal antibodies. A modern panacea for autoimmune disease?

• Gert Riethmueller, K Deusch, +4 authors Ernst Peter Rieber
• Immunology series
• 1993

Antilipid a monoclonal antibody HA-1A: immune complex clearance of endotoxin reduces TNF-alpha, IL-1 beta and IL-6 production.

• Peter D Katsikis, Gianni Harris, +7 authors Peter E. Daddona
• Cytokine
• 1993

HA-1A is a human monoclonal IgM antibody which recognizes the lipid A component of lipopolysaccharide (LPS). This antibody has reduced mortality in the septic shock syndrome resulting from Gram… (More)

Effects of isotype and Fc region on in vitro function of a mouse/human chimeric CD4 antibody.

• M R Dalesandro, Koon Yan Pak, +7 authors Gert Riethmuller
• International immunology
• 1993

Murine CD4 mAbs have shown potential for the treatment of allograft rejection and autoimmune disorders including rheumatoid arthritis. Clinical usefulness of the murine mAbs has been limited by… (More)

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