M.R. D’Apice

Learn More
Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, leading to chromatin damage and cellular senescence and(More)
Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yield mature lamin A. It is of utmost importance to(More)
We refer to our article by Vittoria Cenni et al. published in the European Journal of Histochemistry. 1 We have observed that Figure 1 A and Figure 2 A were not adequate to clearly represent the results we report in the paper. Therefore, we have replaced the pictures with better versions of images reporting the same experiments. In Figure 1A we show that(More)
Comprehensive neuro-rehabilitation of the children with mental problems improved their clinical and emotional background , memory and cognitive functions. EEG and NEC examination marked the trends in recovery of inter-hemispheric connections and in normalization of the bioelectrical activity in the brain. The objective to identify appropriate outcome(More)
  • 1