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Graphical Abstract Highlights d A gradient of BMP signaling maintains the directive axis in Nematostella d BMP signaling regulates Nematostella Hox genes and patterns the endoderm d BMP network topology is similar in Nematostella and Xenopus d Constraint analysis reveals the evolvability of BMP network components In Brief Similar to Bilateria, anthozoans(More)
Chemokines play a key role in directing and driving leucocyte trafficking. The efficient regulation of leucocyte recruitment by chemokines requires their appropriate localization in functional micro-anatomical domains, as well as setting limits to their effects in space and time. Both processes are influenced by silent chemokine receptors (interceptors),(More)
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