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The adaptive cubic regularization method (Cartis et al. in Math. Program. been recently proposed for solving unconstrained minimization problems. At each iteration of this method, the objective function is replaced by a cubic approximation which comprises an adaptive regularization parameter whose role is related to the local Lipschitz constant of the(More)
Oxidative stress plays a major role in ethanol-induced liver damage, and agents with antioxidant properties are promising as therapeutic opportunities in alcoholic liver disease. In the present work, we investigated the effect of S-adenosylmethionine (AdoMet), Tyrosol (Tyr), and their combination on HepG2 cells exposed to ethanol exploring the potential(More)
The present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk. Young overweight men (n = 20), without metabolic syndrome, were placed in a 3-week residential program on a low-fat diet and moderate aerobic exercise. In each subject, pre- and postintervention fasting blood were collected for(More)
Posttranslational hypusine modification of lysine 50 of the eukaryotic initiation factor 5A (eIF-5A) is associated with the function of this factor in cell proliferation and differentiation and is involved in tumor formation, progression and maintenance (for a review see ref. 1). In a Molecular Therapy Issue, Francis et al. report that knock down of(More)
Nucleoside hydrolases (NHs) are a class of metalloproteins that catalyze the irreversible hydrolysis of the N-glycosidic bond of β-ribonucleosides forming ribose and purine or pyrimidine base. In the hyperthermophilic archaeon Sulfolobus solfataricus, two NHs have been purified and extensively characterized. Although these enzymes show different substrate(More)
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