M. Pilar Gil

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Dietary restriction (DR) reduces age-specific mortality and increases lifespan in many organisms. DR elicits a large number of physiological changes, however many are undoubtedly not related to longevity. Whole-genome gene expression studies have typically revealed hundreds to thousands of differentially expressed genes in response to DR, and a key open(More)
The best-characterized type 1 interferon (IFN) signaling pathway depends on signal transducer and activator of transcription 1 (STAT1) and STAT2. The cytokines can, however, conditionally activate all STATs. Regulation of their access to particular signaling pathways is poorly understood. STAT4 is important for IFN-gamma induction, and NK cells are major(More)
CONTEXT The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. OBJECTIVE To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women and their influence on fetal growth and(More)
In this paper, we revisit the problem of the determination of the frequency of occurrence of galactic nova outbursts which involve an oxygen–neon (ONe) white dwarf. The improvement with respect to previous work on the subject derives from the fact that we use the results that our evolutionary calculations provide for the final mass and for the chemical(More)
The evolution of a star of initial mass 9 M⊙, and metallicity Z = 0.02 in a Close Binary System (CBS) is followed in the presence of different mass companions in order to study their influence on the final evolutionary stages and, in particular, on the structure and composition of the remnant components. In order to do that, we study two extreme cases. In(More)
CONTEXT Zinc-α2-Glycoprotein (ZAG) is an adipokine with lipolytic action and is positively associated with adiponectin in adipose tissue. We hypothesize that ZAG may be related with hydrocarbonate metabolism disturbances observed in gestational diabetes mellitus (GDM). OBJECTIVE The aim of this study was to analyze serum ZAG concentration and its(More)
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