M. Pepi

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Embolism of cardiac origin accounts for around 15–30% of ischaemic strokes. Strokes due to cardioembolism are generally severe and early and long-term recurrence and mortality are high. The diagnosis of a cardioembolic source of stroke is frequently uncertain and relies on the identification of a potential cardiac source of embolism in the absence of(More)
This review covers the role of three-dimensional (3D) echocardiography in the diagnosis of heart valve disease. Several factors have contributed to the evolution of this technique, which is currently a simple and routine method: rapid evolution in probe and computer technologies, demonstration that 3D data sets allowed more complete and accurate evaluation(More)
A method has been developed to match corresponding heart regions from functional echocardiographic (Echo) and metabolic fluorine-18-fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) studies in individual patients. Echo and PET images are spatially correlated by determining homologous anatomical landmarks (the two papillary muscles and(More)
Mitral valve (MV) physiopathological function and the effects of surgical repair can be studied through finite element models (FEMs). However, this approach assumes idealized morphology and boundary conditions limiting the analysis to paradigmatic scenarios and precluding patient-specific surgical planning. To overcome this limitation, we integrated into a(More)
BACKGROUND Diabetics have high prevalence of subclinical coronary artery disease (CAD) with typical characteristics (diffuse disease, large calcifications). Although 64-slice multidetector computed tomography (MDCT) coronary angiography has high diagnostic accuracy to detect CAD, its diagnostic performance in diabetics with suspected CAD is unknown. To(More)
Two different methods for semi-automated right ventricular (RV) endocardial border detection from MR images, based on different implementation of level set technique, have been developed and validated. Dynamic, ECG-gated, steady-state free precession short axis images were obtained in 26 consecutive patients. An expert cardiologist provided the “gold(More)
OBJECTIVE To assess the prognostic role of multidetector computed tomography coronary angiography (MDCT-CA) in patients with diabetes with suspected coronary artery disease (CAD). Use of MDCT-CA is increasing in patients with suspected CAD. However, data supporting its prognostic value in patients with diabetes are limited. RESEARCH DESIGN AND METHODS(More)
A framework for computed tomography (CT) and magnetic resonance (MR) image fusion is proposed for potential application in cardiac resynchronization therapy (CRT). The MR dataset has been pre-processed compensating for organ motion induced inter-slices misalignment. The geometrical center alignment of CT and MR short axis (SAX) reconstructed 3D volume has(More)
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality and it is responsible for an increasing resource burden. The identification of patients at high risk for adverse events is crucial to select those who will receive the greatest benefit from revascularization. To this aim, several non-invasive functional imaging modalities(More)