M. Patrício

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The identification of genetic markers associated with oral cancer is considered essential to improve the diagnosis, prognosis, early tumor and relapse detection and, ultimately, to delineate individualized therapeutic approaches. Here, we aimed at identifying such markers. Multiplex Ligation-dependent Probe Amplification (MLPA) analyses encompassing 133(More)
In this paper we are concerned with the elliptic PDEs with highly oscillating coefficients which model the behaviour of composite linear elastic materials. Analytical expressions for the effective coefficients are obtained for the case of layered materials using the theory of homogenisation. Some properties of the homogenised materials are analysed. An(More)
Supplementary Methods MRI and MRS acquisitions Scanning was performed on a 3T Siemens TimTrio (Siemens), using a 12-channel head coil. Acquisitions: (i) T1-weighted MP-RAGE, 1 mm 3 isotropic voxel, repetition time (TR) 2530 ms, echo time (TE) 3.42 ms, inversion time (TI) 1100 ms, flip angle (FA) 7°, field of view (FOV) 256 x 256 mm, 256 x 256 matrix, 176(More)
OBJECTIVE To provide a comprehensive investigation of the γ-aminobutyric acid (GABA) system in patients with neurofibromatosis type 1 (NF1) that allows understanding the nature of the GABA imbalance in humans at pre- and postsynaptic levels. METHODS In this cross-sectional study, we employed multimodal imaging and spectroscopy measures to investigate GABA(More)
In order to ensure the safe usage of new radiopharmaceuticals in Positron Emission Tomography (PET), it is necessary to quantify the doses delivered to the organs and tissues within the patients' bodies. A framework that allows estimating the dose delivered by PET has been established by the MIRD Committee [1,2] and ICRP [3]. Although this covers the most(More)
Understanding the neurobiological mechanisms underlying different types of tremor and the altered functional connectivity of the involved areas is a timely goal in clinical neuroscience. If successful, this quest may open new perspectives on how to achieve tremor modulation, which is notably relevant, in Parkinson's disease (PD). Tremor can be characterized(More)
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