Learn More
  • M. Paoli
  • Progress in biophysics and molecular biology
  • 2001
Many proteins involved in key biological processes are modular in nature. A group of these, the beta-propeller proteins, fold by packing 4-stranded beta-sheets in a circular array. The members of this group are increasingly numerous and, although their modular building blocks all preserve the same basic conformation, they do not have similar sequences.(More)
BACKGROUND Cysteine proteases (cathepsin B [CATB] and cathepsin L [CATL]), the serine protease urokinase-type plasminogen activator (UPA), and plasminogen activator inhibitor type-1 (PAI-1) are thought to play an important part in cancer invasion and metastasis. The aims of this study were to measure CATB, CATL, UPA, and PAI-1 in gastric cancer (GC) and(More)
Recent structure determinations have made new additions to a set of strikingly different sequences that give rise to the same topology. Proteins with a beta propeller fold are characterized by extreme sequence diversity despite the similarity in their three-dimensional structures. Several fold predictions, based in part on sequence repeats thought to match(More)
The ward behavior of 29 inpatients with a diagnosis of major depressive disorder and that of six mixed psychiatric patients was studied by means of an observational method derived from ethological techniques. By these means the occurrence of a wide variety of behaviors was monitored. Depressives before treatment differed from the same group after 4 week of(More)
Biological systems rely on heme-proteins to carry out a number of basic functions essential for their survival. Hemes, or iron-porphyrin complexes, are the versatile and ubiquitous active centers of these proteins. In the past decade, discovery of new heme-proteins, together with functional and structural research, provided a wealth of information on these(More)
Capillary electrophoresis with laser-induced fluorescence was applied to the analysis of six STRs and the amelogenin sex test with the purpose of verifying accuracy and precision of the sizing method with the GS500 internal standard. Sequenced dye-labeled, PCR-amplified alleles from amelogenin, HumVWA31, HumTH01, HumF13A01, HumFIBRA, D21S11 and HumCSF1PO(More)
744 nature structural biology • volume 8 number 9 • september 2001 Determination of protein structures has shown that often distinct sequences are compatible with the same fold. It is believed that the number of possible folds is limited relative to the number of, say, genes in the human genome. Some research efforts therefore aim to structurally(More)
The urokinase-type plasminogen activator (UPA) and its inhibitor PAI-1 are thought to play an important part in gastric cancer (GC) invasion and metastasis. Little is known about the behavior and prognostic impact of the receptor for UPA (UPAR). The aims of the present study were: (1) to measure UPAR, UPA and PAI-1 levels in GC and in non-malignant tissue(More)
The ability to design specific amino acid sequences that fold into desired structures is central to engineering novel proteins. Protein design is also a good method to assess our understanding of sequence-structure and structure-function relationships. While beta-sheet structures are important elements of protein architecture, it has traditionally been more(More)