M. P. Sanz-Moncasi

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The human fibroblast activation protein alpha (FAP alpha) is a M(r) 95,000 cell surface antigen selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. Normal adult tissues are generally FAP alpha-, but some fetal mesenchymal tissues transiently(More)
BACKGROUND The vascular endothelium participates in diverse physiologic and pathologic processes, ranging from blood clotting to leukocyte trafficking and tumor metastasis. Many of these functions are mediated by endothelial surface molecules, and monoclonal antibodies (mAb) have been used extensively to define endothelial cell surface structures in normal(More)
Monoclonal antibodies CC49 and B72.3, which recognize a tumor associated glycoprotein (TAG-72) related to sialyted Tn antigen, have been used in clinical trials for radionuclide imaging, and treatment of colon, breast and ovarian carcinoma. In addition, studies with CC49 in patients with metastatic hormone refractory prostate cancer have been initiated(More)
Nuclear grading of neoplasms has classically been involved in prognosis and must be established by combining different parameters, such as the textural pattern of chromatin, which is subjective and difficult to measure. Mathematical morphology (MM), a branch of mathematics dealing with shapes, and, in particular, the so-called top hat transformation,(More)
In the rat a direct relation exists between the mother's plasma phenylalanine levels and alterations to her offspring's nervous system (Okano et al 1986). For a better understanding of the pathophysiology of maternal hyperphenylalaninaemia, we have studied the synaptosomal development of offspring of hyperphenylalaninaemic rats and the effects of(More)
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