M. P. Robinson

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Models of tissue dielectric properties (permittivity and conductivity) enable the interactions of tissues and electromagnetic fields to be simulated, which has many useful applications in microwave imaging, radio propagation, and non-ionizing radiation dosimetry. Parametric formulae are available, based on a multi-pole model of tissue dispersions, but(More)
Electroporation, the transient increase in the permeability of cell membranes when exposed to a high electric field, is an established in vitro technique and is used to introduce DNA or other molecules into cells. When the trans-membrane voltage induced by an external electric field exceeds a certain threshold (normally 0.2–1 V), a rearrangement of the(More)
This paper describes a method of effectively electroporating mammalian cell membranes with pulsed alternating-current (ac) electric fields at field strengths of 30-160 kV m(-1). Although many in vivo electroporation protocols entail applying square wave or monotonically decreasing pulses via needles or electrode plates, relatively few have explored the use(More)
The aims of this work were to establish whether, in an obese population, a group characterized by a distinctly high fact cell number could be observed and whether the number of body fact cells was affected by slimming. In the obese group there were 75 obese females (kg/m2 greater than 27.0) and 19 obese males (kg/m2 greater than 27.5); the lean group(More)
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect(More)
Electroporation is a long-established technique used to deliver molecules to cells. Most in vivo electroporation protocols entail applying square-wave, or monotonically-decreasing pulses but relatively few have explored the use of pulsed ac fields. This study measures the efficiency of electroporation in human kidney embryonal cells, using pulsed ac(More)
Two novel materials have been developed to simulate the dielectric properties of human muscle and fat at 1000 MHz. These materials, which are based on ethanediol set with gelatine, are easily made and have good mechanical properties. The complex permittivity, epsilon *, of each material was measured with an open-ended coaxial sensor in conjunction with an(More)
In vivo high throughput screening (HTS) has been adopted by most of the larger crop protection companies as an important tool for the discovery of new agrochemicals. There has been a paradigm shift in capabilities from screening a few thousand compounds a year to several hundred thousand and the quantity of screening sample required has fallen dramatically.(More)