M. P. Peremyuk

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We have already reported [1, 2] that der ivat ives of pyrimido-(4,5-b)-(1,4)thiazine containing amino or oxo groups in the 6-posit ion of the molecule exhibit an antifolic activity. In continuation of these investigations, s we synthesized 9-oxo-6,7,8,9-tetrahydropyrimido(4,5-b)(1,4)benzothiazines (Ia-g, IIa, b) (Table 1), which can be considered vinylogs(More)
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