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A randomized phase II study of BB-10010: a variant of human macrophage inflammatory protein-1alpha for patients receiving high-dose etoposide and cyclophosphamide for malignant lymphoma and breast…
Macrophage inflammatory protein-1alpha (MIP-1alpha) is a chemokine that can inhibit the cell cycle progression of both primitive haemopoietic and epidermal progenitor cells. This property could… Expand
Pulmonary pharmacology of a novel, smooth muscle-selective muscarinic antagonist in vivo.
- R. Howell, K. Laemont, +4 authors L. Noronha-Blob
- The Journal of pharmacology and experimental…
- 1 August 1994
The need for a smooth muscle-selective muscarinic antagonist that could provide oral bronchodilator activity with minimal side effects has led to the discovery of… Expand
Hypotensive effect of an M2-selective muscarinic antagonist in anaesthetized guinea-pigs.
1. In order to determine an involvement of muscarinic M2 receptors in the regulation of systemic arterial blood pressure, we investigated the cardiovascular effects of the M2-selective antagonist… Expand
A randomized phase II study of BB‐10010: a variant of human macrophage inflammatory protein‐1α for patients receiving high‐dose etoposide and cyclophosphamide for malignant lymphoma and breast cancer
Macrophage inflammatory protein‐1α (MIP‐1α) is a chemokine that can inhibit the cell cycle progression of both primitive haemopoietic and epidermal progenitor cells. This property could potentially… Expand
Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
- R. Howell, M. Kovalsky, K. Laemont
- Chemistry, Medicine
- European journal of pharmacology
- 14 November 1994
We investigated the effects of subtype-selective muscarinic receptor antagonists upon aerosol antigen-induced bronchoconstriction in anesthetized guinea pigs. Neither pirenzepine (muscarinic M1… Expand