M. P. H. Wolff

Learn More
Stimulation of the Jun NH(2)-terminal kinase/stress-activated protein kinase (JNK/SAPK) and the p38 mitogen-activated protein kinase (p38/MAPK) is part of the stress-related signal transduction pathways conveying signals from the cell surface into the nucleus in order to initiate programmes of gene expression. Here, it was shown that infection by(More)
Varicella-zoster virus (VZV) is sensitive to type I and type II interferons (IFNs), which mediate antiviral effects. In this study, it was demonstrated that IFN-beta and IFN-gamma inhibited the replication of VZV in vitro. Although IFN-beta was more effective than IFN-gamma, the level of inhibition of VZV replication achieved by the combination of both IFNs(More)
The expression of the genes of varicella-zoster virus (VZV) is regulated by self-encoded viral as well as cellular transcription factors. A potential candidate with an ability to influence the transcription of VZV genes is USF (upstream stimulatory factor), which recognizes the consensus E-box motif. Quantitative RT-PCR and immunoblot assays indicate stable(More)
We discuss conditions such that strong stability and strong as-ymptotic compactness of a (discrete or continuous) semiflow defined on a subset in the positive cone of an ordered Banach space is preserved under asymptotic domination. This is used to show that on a Banach lattice with order continuous norm strong stability and almost periodicity of a(More)
Several chemical disinfectants have been tested in a quantitative suspension test for virucidal activity as per the test method devised by the German Society for Control of Viral Diseases (DVV) and the former German Federal Health Office (BGA, now the Robert Koch-Institute, RKI) drafted in 1982. The introduction of the term "limited virucidal activity"(More)
Let E be a Banach space over C and let the densely defined closed linear operator A: D(A) … E Q E be discretely approximated by the sequence ((A n , D(A n))) n ¥ N of operators A n where each A n is densely defined in the Banach space F n. Let s a (A) be the approximate point spectrum of A and let s e (A n) denote the e-pseudospectrum of A n. Generalizing(More)
Varicella-zoster virus (VZV) is ultimately dependent upon its host cell for replication. To ensure its reproduction, VZV reorganizes various cellular functions by taking advantage of pre-existing signalling pathways. Recently, it was demonstrated that the activation of stress-related mitogen-activated protein kinase pathways following infection led to(More)
  • 1