M. P. Gorizontova

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The intensity of clinical manifestations (rubbing of the oro-facial area with skin injury), bioelectric activity of the somatosensory cortex and microcirculatory disturbances were studied for 6 weeks in Wistar rats with partial infraorbital nerve compression. These parameters were compared among rats of the following groups: without skin rubbing (1), with(More)
After cutting the sciatic nerve in rats, clofelin and propranolol were tested for effects on the development of the pain syndrome. It was found that in rats receiving neither clofelin nor propranolol, the cutting of the sciatic nerve resulted in hyperalgesia, autotomies, increased amplitude of evoked potentials in the contralateral somatosensory cortex(More)
Immobilization of rats for 1 or 3 h leads to an increase in vascular permeability for ink particles and disturbances of the microcirculation in the mesenteric microvessels (formation of aggregates, appearance of “plasmatic vessels,” closure of arteriolar-venular shunts). An important role in the pathogeneis of these changes is played by histamine liberated(More)
A method of quantitative evaluation of disturbances of permeability of microvessels for particles of colloidal carbon with the aid of a television analyzing system is described. Advantages of the method include automation and high accuracy of the measurements.
Prophylactic injection of pentoxyphylline into rats with a neuropathic pain syndrome produced by sciatic nerve transection delayed and weakened the development of this syndrome, improved the microcirculation and venular permeability, and reduced mast cell degranulation. The findings of this study recommend pentoxyphylline for clinical use in the multidrug(More)
Biomicroscopic studies of rat mesentery during 24-hours immobilization have shown phasic changes in globulin-FITC transport in the system: venule-interstitial-lymphatic microvessel. During short immobilization we have discovered the increasing contraction of lymphatic microvessels; during long immobilization--the decreasing contraction has been discovered.
Disturbances of vascular permeability were studied by the "vascular labeling" technique in the mesentry during the 24-hour immobilization of rats. Administration of dimebolin (an antihistaminic preparation) decreased the number of labeled vessels and labeling intensity. This effect was expressed in the presence of mast cells only and was accompanied by the(More)