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Pulses of low intensity current, delivered through a cuff electrode chronically implanted around the optic nerve of a blind retinitis pigmentosa patient generate visual sensations. These phosphenes are obtained at lower thresholds for a train of stimuli than for single pulses, which suggests the existence of a spatial and temporal integrating mechanism. The(More)
In blind subjects who still have functional retinal ganglion cells, electrical stimuli applied to the optic nerve can produce localised visual sensations. This has been demonstrated with an intracranially implanted self-sizing spiral cuff electrode, but, to avoid skull opening, intra-orbital cuff implantation is now considered. In its orbital segment, the(More)
Several experimental data about membrane dynamics and pharmacological sensitivities of optic nerve axons have been published. The present work summarizes these data and computer simulations have been used to develop a model of the mammalian optic nerve fibre. The ionic currents description were derived from existing membrane models and particularly from a(More)
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