M Nieto Barrera

Learn More
AIMS Severe myoclonic epilepsy in infancy (SMEI) is an epileptic syndrome recognised by the ICE of 1985 and 1989 and in the proposal put forward by the ILAE Task Force on Classification and Terminology in 2001. In this paper, its historical development, nosological characteristics and treatment are described. DEVELOPMENT Although identified by Dravet in(More)
While CRISPR/Cas9 technology has proven to be a valuable system to generate gene-targeted modified animals in several species, this tool has been scarcely reported in farm animals. Myostatin is encoded by MSTN gene involved in the inhibition of muscle differentiation and growth. We determined the efficiency of the CRISPR/Cas9 system to edit MSTN in sheep(More)
Lentiviral technology has been recently proposed to generate transgenic farm animals more efficiently and easier than traditional techniques. The objective was to evaluate several parameters of lambs obtained by lentiviral transgenesis in comparison with non-transgenic counterparts. In vitro produced embryos were microinjected (TG group) at two-cell stage(More)
mental Animal Unit of IPMon and the Instituto de Reproducción Animal de Uruguay (IRAUy). The main objective was to update the state of the art of animal transgenic technologies for participants worldwide, focusing in spreading these technologies to emerging countries of South America and the Caribbean. Several topics in large and small animals were(More)
INTRODUCTION The International Classification of epilepsies and epileptic syndromes, proposed in 1989, have proven to be of considerable value and suministered a universal vocabulary for physicians. The use have identified also some disadvantages and the rapid advances in neuroimage and molecular genetics has become clear that reappraisal is needed. (More)
OBJECTIVE The association of a language disorder with epilepsy is observed in some circumstance, with or without a causal relationship. In Landau-Kleffner syndrome (LKS), it is estimated that the aphasia is directly caused by epileptic discharges in language areas. PATIENTS AND METHODS Ten children with LKS are studied. The clinical and(More)
64 children with seizures occuring during sleep were studied. No claim is made to definitive clinical results, but the clinical peculiarities of certain epileptic crises that tend to occur more frequently in sleep are presented. In 62.5% of all our cases are being treated as benign epilepsy, with centro-temporal E.E.G. foci and typical characteristics of(More)
  • 1