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High serum levels of endotoxin and cytokines, through which its activity is mediated, have been shown to be associated with disease severity in septic shock and in fulminant hepatic failure. In the present study, we have investigated the ability of activated charcoals (DHP-1 and Adsorba 150C) and uncharged resin (Amberlite XAD-7) to adsorb(More)
In vitro plasma perfusion experiments were performed using small columns containing either resin or charcoal adsorbents to assess the removal of cytokines and endotoxin. 125I-labelled tumor necrosis factor-alpha (TNF-alpha; 500 pg/ml) and interleukin-6 (IL-6; 10 ng/ml) were added individually to human plasma. Over 4 hr of perfusion, Amberlite XAD-7 resin(More)
Many of the profound effects of staphylococcal septicaemia are thought to be the result of entry of enterotoxins into the systemic circulation. The aim of this study was to investigate the disposition of staphylococcal enterotoxin A (SEA) in the rat and its possible removal from blood. SEA labelled with 125I was administered intravenously (250(More)
In an attempt to elucidate the functions of three types of filiform papillae in the rat's tongue, corrosive resin casts of the microvessels in the filiform papillae were observed under the scanning electron microscope. The filiform papillae were also examined by light and transmission electron microscopy. The three dimensional architecture of the(More)
A new, third type of secretory cell was found in the acini of the submandibular gland in rat. In paraffin sections stained with hematoxylin-eosin or reacted with periodic acid-Schiff, acini containing the third type of secretory cells were found as a mass of darkly stained secretory endpieces at the periphery of the lobule. In semi-thin sections stained(More)
In an attempt to elucidate the functions of three types of filiform papillae in the rat's tongue, corrosive resin casts of the microvessels in the filiform papillae were observed under the scanning electron microscope. The filiform papillae were also examined by light and transmission electron microscopy. The three dimensional architecture of the(More)
In addition to seromucous cells and a few mucous cells (Type II cells), submandibular glands of 2-8 month old rats contain two additional cell types: type III and type IV. Type III cells contain serous-type secretory granules that sometimes have a complex substructure; type IV cells appear to be seromucous, but their granules clearly are different from(More)
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