M. N. Lebedyuk

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Intercalation into DNA is believed to play a key role in the antiviral and interferon inductor activity of amyxin and its analogs [1 – 3]. This hypothesis has mostly been confirmed by the results of investigation of the properties of aminoacridine derivatives, which demonstrated the intercalating properties of 9-aminoacridine and a series of acridinylamino(More)
Since diazepam is a highly effective antiepileptic agent, it was important to investigate the effect of this drug on an epilepti~ complex. The effects of diazepam were studied on the whole brain and also on cerveau isole, cortex isol~, and hemisphSre isole preparations. By using these brain preparations it was possible to obtain additional information on(More)
The dependence of the affinity of compounds to DNA on the structure of their fragments intercalating into the double helix was studied in a series of aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene. The synthesized compounds were characterized by the intercalating properties and the ability to inhibit the polymerase chain reaction (PCR).(More)
Combilexeins are high-affinity DNA ligands with a structure comprising both recognition (lexitropsin) and functional (intercalator, alkylating fragment, etc.) groups. These molecules have drawn the attention of researchers due to a unique combination of properties, whereby highly specific binding of lexitropsin is retained together with a high biological(More)
Understanding the mechanisms of biological action of xenobiotics is a necessary condition for the targeted synthesis of promising drugs. This knowledge is especially important for the development of antiviral preparations, since the obligate parasitism of viruses leads to difficulties in differentiating pathological and normal processes in the living cell(More)
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